ANTIBODIES TO TISSUE-TYPE PLASMINOGEN ACTIVATOR (tPA) IN PATIENTS WITH ANTIPHOSPHOLIPID SYNDROME. EVIDENCE OF INTERACTION BETWEEN THE ANTIBODIES AND THE CATALYTIC DOMAIN OF tPA IN TWO PATIENTS Anti-tPA antibodies in antiphospholipid syndrome
نویسندگان
چکیده
Massimo Cugno1, Mara Cabibbe1, Monica Galli 2, Pier Luigi Meroni3, Sonia Caccia4, Rosaria Russo4, Bianca Bottasso1, Pier Mannuccio Mannucci.1 1Department of Internal Medicine and Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital and University of Milan, Milan, Italy. 2Department of Hematology, Ospedali Riuniti, Bergamo, Italy. 3Department of Internal Medicine, University of Milan, Istituto Auxologico Italiano IRCCS, Milan, Italy. 4Department of Biomedical Sciences and Technologies, University of Milan, Milan, Italy.
منابع مشابه
Autoantibodies against the fibrinolytic receptor, annexin 2, in antiphospholipid syndrome.
The association of thrombosis and gestational morbidity with antiphospholipid antibodies is termed antiphospholipid syndrome (APS). Annexin 2 (A2) is a profibrinolytic endothelial cell surface receptor that binds plasminogen, its tissue activator (tPA), and beta(2)-glycoprotein I (beta2GPI), the main antigen for antiphospholipid antibodies. Here, we evaluate A2 as a target antigen in APS. Serum...
متن کاملP-75: The Association of Antiphospholipid Syndrome and Recurrent Miscarriages
a:4:{s:10:"Background";s:364:"Antiphospholipid syndrome is a coagulation disorder that causes recurrent miscarriages and fetal deaths. In the present review we summarize current knowledge about Antiphospholipid syndrome that associated with recurrent miscarriages. In addition, on the basis of these comprehensive data, possible pathophysiologic mechanisms of this disorder are discussed.";s:19:"M...
متن کاملRevisiting Beta 2 Glycoprotein I, the Major Autoantigen in the Antiphospholipid Syndrome
Beta 2 glycoprotein I (β2GPI) is a single chain 50 kDa highly glycosylated glycoprotein at an approximate concentration of 4 μM in cells. The abundance of this protein in plasma and its high state of preservation indicate the important role of this protein in mammalian. In addition, β2GPI has a particular structure in the fifth domain, and is categorized as the major antigen recognized by autoa...
متن کاملDysfunction in the coagulation system and schizophrenia
Although different hypotheses have been formulated to explain schizophrenia pathogenesis, the links between them are weak. The observation that five psychotic patients on chronic warfarin therapy for deep-vein thrombosis showed long-term remission of psychotic symptoms made us suspect that abnormalities in the coagulation pathway, specifically low tissue plasminogen activator (tPA) activity, co...
متن کاملPrevalence of Antiphospholipid Antibodies in Syrian Patients with Thrombosis
Background: Antiphospholipid antibodies (aPL) are a heterogeneous family of anti-bodies associated with thrombosis and other complications. Objective: To study the prevalence of aPL in patients with thrombosis at Aleppo University Hospitals, Syria. Methods: One hundred and fifty-seven patients with venous and arterial thrombosis and 63 healthy controls were studied. Anticardiolipin antibodies (...
متن کامل